Relevanteste Publikationen:
1. Neurophysiology (EEG/aEEG/VEP)
Mader J, Hartmann M, Klebermass-Schrehof K, Werther T, Dressler A, Oberdorfer L, Pointner N, Fuiko R, Berger A, Kluge T, Giordano V. Automated estimation of EEG maturity in preterm neonates and its association with long-term outcome. Clin Neurophysiol. 2025 Nov 11;181:2111432. doi: 10.1016/j.clinph.2025.2111432. Epub ahead of print. PMID: 41240447.
Mader J, Hartmann M, Dressler A, Oberdorfer L, Rona Z, Glatter S, Czaba-Hnizdo C, Herta J, Kluge T, Werther T, Berger A, Koren J, Klebermass-Schrehof K, Giordano V. Adaptive threshold algorithm for detecting EEG-interburst intervals in extremely preterm neonates. Physiol Meas. 2024 Oct 1;45(9). doi: 10.1088/1361-6579/ad7c05. PMID: 39288793.
Stevenson NJ, Nordvik T, Espeland CN, Giordano V, Moltu SJ, Larsson PG, Klebermaß-Schrehof K, Stiris T, Vanhatalo S. Inter-site generalizability of EEG based age prediction algorithms in the preterm infant. Physiol Meas. 2023 Jul 31;44(7). doi: 10.1088/1361-6579/ace755. PMID: 37442141.
Iyer KK, Leitner U, Giordano V, Roberts JA, Vanhatalo S, Klebermass-Schrehof K, Stevenson NJ. Bedside tracking of functional autonomic age in preterm infants. Pediatr Res. 2023 Jul;94(1):206-212. doi: 10.1038/s41390-022-02376-2. Epub 2022 Nov 14. PMID: 36376508.
Ramantani G, Schmitt B, Plecko B, Pressler RM, Wohlrab G, Klebermass-Schrehof K, Hagmann C, Pisani F, Boylan GB. Neonatal Seizures-Are We there Yet? Neuropediatrics. 2019 Oct;50(5):280-293. doi: 10.1055/s-0039-1693149. Epub 2019 Jul 24. PMID: 31340400.
Schwindt E, Giordano V, Rona Z, Czaba-Hnizdo C, Olischar M, Waldhoer T, Werther T, Fuiko R, Berger A, Klebermass-Schrehof K. The impact of extrauterine life on visual maturation in extremely preterm born infants. Pediatr Res. 2018 Sep;84(3):403-410. doi: 10.1038/s41390-018-0084-y. Epub 2018 Jun 2. PMID: 29967524.
Stevenson NJ, Oberdorfer L, Koolen N, O'Toole JM, Werther T, Klebermass-Schrehof K, Vanhatalo S. Functional maturation in preterm infants measured by serial recording of cortical activity. Sci Rep. 2017 Oct 11;7(1):12969. doi: 10.1038/s41598-017-13537-3. PMID: 29021546; PMCID: PMC5636845.
Koolen N, Oberdorfer L, Rona Z, Giordano V, Werther T, Klebermass-Schrehof K, Stevenson N, Vanhatalo S. Automated classification of neonatal sleep states using EEG. Clin Neurophysiol. 2017 Jun;128(6):1100-1108. doi: 10.1016/j.clinph.2017.02.025. Epub 2017 Mar 15. PMID: 28359652.
Klebermass-Schrehof K, Rona Z, Waldhör T, Czaba C, Beke A, Weninger M, Olischar M. Can neurophysiological assessment improve timing of intervention in posthaemorrhagic ventricular dilatation? Arch Dis Child Fetal Neonatal Ed. 2013 Jul;98(4):F291-7. doi: 10.1136/archdischild-2012-302323. Epub 2012 Dec 20. PMID: 23258839.
Klebermass K, Olischar M, Waldhoer T, Fuiko R, Pollak A, Weninger M. Amplitude-integrated EEG pattern predicts further outcome in preterm infants. Pediatr Res. 2011 Jul;70(1):102-8. doi: 10.1203/PDR.0b013e31821ba200. PMID: 21436758.
Klebermass K, Kuhle S, Olischar M, Rücklinger E, Pollak A, Weninger M. Intra- and extrauterine maturation of amplitude-integrated electroencephalographic activity in preterm infants younger than 30 weeks of gestation. Biol Neonate. 2006;89(2):120-5. doi: 10.1159/000088912. Epub 2005 Oct 11. PMID: 16219998.
Olischar M, Klebermass K, Kuhle S, Hulek M, Kohlhauser C, Rücklinger E, Pollak A, Weninger M. Reference values for amplitude-integrated electroencephalographic activity in preterm infants younger than 30 weeks' gestational age. Pediatrics. 2004 Jan;113(1 Pt 1):e61-6. doi: 10.1542/peds.113.1.e61. PMID: 14702497.
Kuhle S, Klebermass K, Olischar M, Hulek M, Prusa AR, Kohlhauser C, Birnbacher R, Weninger M. Sleep-wake cycles in preterm infants below 30 weeks of gestational age. Preliminary results of a prospective amplitude-integrated EEG study. Wien Klin Wochenschr. 2001 Apr 17;113(7-8):219-23. PMID: 11383380.
2. MRI
Buchmayer, J; Stummer, S; Fuiko, R; Kasprian, G; Klebermaß-Schrehof, K; Berger, A, Goeral, K
Neurodevelopmental Outcomes of Cerebellar Pathologies in Extremely Preterm Infants
In Review
Buchmayer, J; Fuiko, R; Kienast, P; Stummer, S; Kasprian, G; Berger, A; Goeral, K
Cerebellar haemorrhage and atrophy in infants born extremely preterm with intraventricular haemorrhage
Dev Med Child Neurol. 2024; doi: 10.1111/dmcn.16123
Buchmayer, J; Kasprian, G; Jernej, R; Stummer, S; Schmidbauer, V; Giordano, V; Klebermass-Schrehof, K; Berger, A; Goeral, K
Magnetic Resonance Imaging-Based Reference Values for Two-Dimensional Quantitative Brain Metrics in a Cohort of Extremely Preterm Infants
Neonatology. 2023; doi: 10.1159/000534009
Buchmayer, J; Kasprian, G; Giordano, V; Schmidbauer, V; Steinbauer, P; Klebermass-Schrehof, K; Berger, A; Goeral, K
Routine Use of Cerebral Magnetic Resonance Imaging in Infants Born Extremely Preterm
J Pediatr. 2022; doi: 10.1016/j.jpeds.2022.05.033
Schmidbauer VU, Yildirim MS, Dovjak GO, Goeral K, Buchmayer J, Weber M, Kienast P, Diogo MC, Prayer F, Stuempflen M, Kittinger J, Malik J, Nowak NM, Klebermass-Schrehof K, Fuiko R, Berger A, Prayer D, Kasprian G, Giordano V. Quantitative Magnetic Resonance Imaging for Neurodevelopmental Outcome Prediction in Neonates Born Extremely Premature-An Exploratory Study. Clin Neuroradiol. 2024 Jun;34(2):421-429. doi: 10.1007/s00062-023-01378-9. Epub 2024 Jan 30. PMID: 38289377; PMCID: PMC11129968.
Steiner M, Schwarz H, Kasprian G, Rittenschober-Boehm J, Schmidbauer V, Fuiko R, Olischar M, Klebermass-Schrehof K, Berger A, Goeral K. Brain Biometry Reveals Impaired Brain Growth in Preterm Neonates with Intraventricular Hemorrhage. Neonatology. 2023;120(2):225-234. doi: 10.1159/000528981. Epub 2023 Feb 20. PMID: 36805535; PMCID: PMC10906469.
Goeral K, Kasprian G, Hüning BM, Waldhoer T, Fuiko R, Schmidbauer V, Prayer D, Felderhoff-Müser U, Berger A, Olischar M, Klebermass-Schrehof K. A novel magnetic resonance imaging-based scoring system to predict outcome in neonates born preterm with intraventricular haemorrhage. Dev Med Child Neurol. 2022 May;64(5):608-617. doi: 10.1111/dmcn.15116. Epub 2021 Nov 28. PMID: 34839534; PMCID: PMC9299734.
Goeral K, Schwarz H, Hammerl M, Brugger J, Wagner M, Klebermass-Schrehof K, Kasprian G, Kiechl-Kohlendorfer U, Berger A, Olischar M. Longitudinal Reference Values for Cerebral Ventricular Size in Preterm Infants Born at 23-27 Weeks of Gestation. J Pediatr. 2021 Nov;238:110-117.e2. doi: 10.1016/j.jpeds.2021.06.065. Epub 2021 Jun 29. PMID: 34214587.
3. NIRS
Bruckner M, Suppan T, Suppan E, Schwaberger B, Urlesberger B, Goeral K, Hammerl M, Perme T, Dempsey EM, Springer L, Lista G, Szczapa T, Fuchs H, Karpinski L, Bua J, Law B, Buchmayer J, Kiechl-Kohlendorfer U, Cerar LK, Schwarz CE, Gründler K, Stucchi I, Klebermass-Schrehof K, Schmölzer GM, Pichler G. Brain oxygenation monitoring during neonatal stabilization and resuscitation and its potential for improving preterm infant outcomes: a systematic review and meta-analysis with Bayesian analysis. Eur J Pediatr. 2025 Apr 21;184(5):305. doi: 10.1007/s00431-025-06138-0. PMID: 40259049; PMCID: PMC12011959.
Wolfsberger CH, Schwaberger B, Avian A, Goeral K, Hammerl M, Perme T, Dempsey EM, Springer L, Lista G, Szczapa T, Fuchs H, Karpinski L, Bua J, Law BHY, Buchmayer J, Kiechl-Kohlendorfer U, Kornhauser-Cerar L, Schwarz CE, Gründler K, Stucchi I, Klebermass-Schrehof K, Schmölzer GM, Pichler G; COSGOD III study group. Reference values of cerebral fractional tissue oxygen extraction (cFTOE) in preterm neonates during immediate fetal-to-neonatal transition: A secondary outcome analysis of the COSGOD III trial. Neonatology. 2025 Dec 4:1-18. doi: 10.1159/000549465. Epub ahead of print. PMID: 41343435.
Perme T, Kornhauser Cerar L, Schwaberger B, Urlesberger B, Wolfsberger CH, Baik N, Goeral K, Hammerl M, Dempsey EM, Springer L, Lista G, Szczapa T, Fuchs H, Karpinski L, Bua J, Avian A, Law BHY, Buchmayer J, Kiechl-Kohlendorfer U, Schwarz CE, Gruendler K, Stucchi I, Klebermass-Schrehof K, Schmölzer GM, Pichler G; COSGOD III study group. Effect of timing of umbilical cord clamping on cerebral regional tissue oxygenation: a secondary analysis of the COSGOD III trial. Arch Dis Child Fetal Neonatal Ed. 2025 Oct 17;110(6):610-615. doi: 10.1136/archdischild-2024-327946. PMID: 40306760.
Norooz F, Urlesberger B, Giordano V, Klebermasz-Schrehof K, Weninger M, Berger A, Olischar M. Decompressing posthaemorrhagic ventricular dilatation significantly improves regional cerebral oxygen saturation in preterm infants. Acta Paediatr. 2015 Jul;104(7):663-9. doi: 10.1111/apa.12942. Epub 2015 Feb 19. PMID: 25619108.
Steiner M, Elis J, Giordano V, Kienast P, Ciglar L, Langs G, Vignolle GA, Olischar M, Berger A, Goeral K. Acute impact of posthemorrhagic ventricular dilatation on cerebral oxygenation in preterm infants with intraventricular haemorrhage. Acta Paediatr. 2024 Dec;113(12):2573-2581. doi: 10.1111/apa.17375. Epub 2024 Aug 8. PMID: 39115973.
4. Pain, Sedation, & Wellbeing
Steinbauer P, Kühnl J, Pichler K, Stummer S, Klebermass-Schrehof K, Deindl P, Lindtner C, Olischar M, Brandstetter S, Fuiko R, Berger A, Giordano V. Cognitive, motor, and behavioral outcomes in preterm infants exposed to opioids. Pediatr Res. 2025 Sep;98(3):918-927. doi: 10.1038/s41390-025-04048-3. Epub 2025 Apr 12. PMID: 40221633; PMCID: PMC12507652.
Pichler K, Kuehne B, Dekker J, Stummer S, Giordano V, Berger A, Kribs A, Klebermass-Schrehof K. Assessment of Comfort during Less Invasive Surfactant Administration in Very Preterm Infants: A Multicenter Study. Neonatology. 2023;120(4):473-481. doi: 10.1159/000530333. Epub 2023 Jun 13. PMID: 37311430; PMCID: PMC10614453.
Giordano V, Fuiko R, Witting A, Unterasinger L, Steinbauer P, Bajer J, Farr A, Hoehl S, Deindl P, Olischar M, Berger A, Klebermass-Schrehof K. The impact of pandemic restrictive visiting policies on infant wellbeing in a NICU. Pediatr Res. 2023 Sep;94(3):1098-1103. doi: 10.1038/s41390-023-02562-w. Epub 2023 Mar 23. PMID: 36959317; PMCID: PMC10034238.
Arribas C, Cavallaro G, Gonzalez JL, Lagares C, Raffaeli G, Smits A, Simons SHP, Villamor E, Allegaert K, Garrido F; ESPR Special Interest Group for Neonatal Pain. Global cross-sectional survey on neonatal pharmacologic sedation and analgesia practices and pain assessment tools: impact of the sociodemographic index (SDI). Pediatr Res. 2024 Sep;96(4):964-975. doi: 10.1038/s41390-024-03032-7. Epub 2024 Feb 13. PMID: 38351093.
Giordano V, Edobor J, Deindl P, Wildner B, Goeral K, Steinbauer P, Werther T, Berger A, Olischar M. Pain and Sedation Scales for Neonatal and Pediatric Patients in a Preverbal Stage of Development: A Systematic Review. JAMA Pediatr. 2019 Dec 1;173(12):1186-1197. doi: 10.1001/jamapediatrics.2019.3351. PMID: 31609437.
Giordano V, Deindl P, Goeral K, Czaba C, Weninger M, Berger A, Olischar M, Werther T. The power of N-PASS, aEEG, and BIS in detecting different levels of sedation in neonates: A preliminary study. Paediatr Anaesth. 2018 Dec;28(12):1096-1104. doi: 10.1111/pan.13509. Epub 2018 Oct 29. PMID: 30375123.
Felnhofer A, Goreis A, Weiss L, Winder J, Marceta-Pavlovic S, Palmisani F, Giordano V, Wagner M, Greber-Platzer S, Metzelder M, Krois W, Kothgassner OD. Effects of Virtual Reality Distraction on Pain, Stress, and Heart Rate During Pediatric Ingrown Toenail Surgery: A Randomized Controlled Trial. J Pediatr Surg. 2025 Dec;60(12):162696. doi: 10.1016/j.jpedsurg.2025.162696. Epub 2025 Sep 26. PMID: 41016553.
Steinbauer P, Bichler M, Fuiko R, Seferagic S, Haas H, Lisy T, Weinmüller S, Berger A, Olischar M, Panagl A, Giordano V. CARTOON-based educational intervention for children to foster hygiene knowledge and emotional resilience in preschool children: a randomized controlled trial. Front Pediatr. 2025 Apr 11;13:1514793. doi: 10.3389/fped.2025.1514793. PMID: 40292121; PMCID: PMC12021609.
Deindl P, Luister A, Vettorazzi E, Pointner N, Singer D, Berger A, Wagner M, Giordano V. Eyes on Newborns: How NICU Staff's Attention and Emotions Shape Neonatal Pain Assessment. Eur J Pain. 2025 Mar;29(3):e4791. doi: 10.1002/ejp.4791. PMID: 39899268; PMCID: PMC11789839.
Giordano V, Luister A, Vettorazzi E, Wonka K, Pointner N, Steinbauer P, Wagner M, Berger A, Singer D, Deindl P. Comparative analysis of artificial intelligence and expert assessments in detecting neonatal procedural pain. Sci Rep. 2024 Sep 2;14(1):20374. doi: 10.1038/s41598-024-71278-6. PMID: 39223215; PMCID: PMC11369161.
Steinbauer P, Lisy T, Monje FJ, Chwala E, Wildner B, Schned H, Deindl P, Berger A, Giordano V, Olischar M. Impact of neonatal pain and opiate administration in animal models: A meta-analysis concerning pain threshold. Early Hum Dev. 2024 Jun;193:106014. doi: 10.1016/j.earlhumdev.2024.106014. Epub 2024 Apr 26. PMID: 38701669.
Giordano V, Deindl P, Gal E, Unterasinger L, Fuiko R, Steinbauer P, Weninger M, Berger A, Olischar M. Pain and neurodevelopmental outcomes of infants born very preterm. Dev Med Child Neurol. 2023 Aug;65(8):1043-1052. doi: 10.1111/dmcn.15505. Epub 2023 Jan 17. PMID: 36647629.
Giordano V, Luister A, Reuter C, Czedik-Eysenberg I, Singer D, Steyrl D, Vettorazzi E, Deindl P. Audio Feature Analysis for Acoustic Pain Detection in Term Newborns. Neonatology. 2022;119(6):760-768. doi: 10.1159/000526209. Epub 2022 Sep 16. PMID: 36116434.
Steinbauer P, Monje FJ, Kothgassner O, Goreis A, Eva C, Wildner B, Schned H, Deindl P, Seki D, Berger A, Olischar M, Giordano V. The consequences of neonatal pain, stress and opiate administration in animal models: An extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes. Neurosci Biobehav Rev. 2022 Jun;137:104661. doi: 10.1016/j.neubiorev.2022.104661. Epub 2022 Apr 12. PMID: 35427643.
Mauritz MD, Uhlenberg F, Bashir-Elahi D, Werther T, Gottschalk U, Ebenebe CU, Bergers M, Giordano V, Vettorazzi E, Singer D, Deindl P. Prediction of Nociception in Children Using the Nociceptive Flexion Reflex Threshold and the Bispectral Index-A Prospective Exploratory Observational Study. Pediatr Crit Care Med. 2021 Sep 1;22(9):e461-e470. doi: 10.1097/PCC.0000000000002701. PMID: 33710075.
Steinbauer P, Deindl P, Fuiko R, Unterasinger L, Cardona F, Wagner M, Edobor J, Werther T, Berger A, Olischar M, Giordano V. Long-term impact of systematic pain and sedation management on cognitive, motor, and behavioral outcomes of extremely preterm infants at preschool age. Pediatr Res. 2021 Feb;89(3):540-548. doi: 10.1038/s41390-020-0979-2. Epub 2020 May 26. PMID: 32454516.
5. Acoustic, Language, and Music
Stummer S, Reuter C, Czedik-Eysenberg I, Bertsch M, Klebermass-Schrehof K, Mader J, Buchmayer J, Bartha-Doering L, Berger A, Giordano V. "Every breath you take": evaluating sound levels and acoustic characteristics of various neonatal respiratory support and ventilation modalities. Front Pediatr. 2024 Apr 19;12:1379249. doi: 10.3389/fped.2024.1379249. PMID: 38706923; PMCID: PMC11066168.
Giordano V, Alexopoulos J, Spagna A, Benavides-Varela S, Peganc K, Kothgassner OD, Klebermass-Schrehof K, Olischar M, Berger A, Bartha-Doering L. Accent discrimination abilities during the first days of life: An fNIRS study. Brain Lang. 2021 Dec;223:105039. doi: 10.1016/j.bandl.2021.105039. Epub 2021 Oct 19. PMID: 34678622.
Bartha-Doering L, Alexopoulos J, Giordano V, Stelzer L, Kainz T, Benavides-Varela S, Wartenburger I, Klebermass-Schrehof K, Olischar M, Seidl R, Berger A. Absence of neural speech discrimination in preterm infants at term-equivalent age. Dev Cogn Neurosci. 2019 Oct;39:100679. doi: 10.1016/j.dcn.2019.100679. Epub 2019 Jul 10. PMID: 31437736; PMCID: PMC6969359.
Giordano V, Goeral K, Schrage-Leitner L, Berger A, Olischar M. The Effect of Music on aEEG Cyclicity in Preterm Neonates. Children (Basel). 2021 Mar 9;8(3):208. doi: 10.3390/children8030208. PMID: 33803493; PMCID: PMC8000223.
Reuter C, Bartha-Doering L, Czedik-Eysenberg I, Maeder M, Bertsch MA, Bibl K, Deindl P, Berger A, Giordano V. Living in a box: Understanding acoustic parameters in the NICU environment. Front Pediatr. 2023 Mar 27;11:1147226. doi: 10.3389/fped.2023.1147226. PMID: 37051427; PMCID: PMC10083238.
Bertsch M, Reuter C, Czedik-Eysenberg I, Berger A, Olischar M, Bartha-Doering L, Giordano V. The "Sound of Silence" in a Neonatal Intensive Care Unit-Listening to Speech and Music Inside an Incubator. Front Psychol. 2020 May 26;11:1055. doi: 10.3389/fpsyg.2020.01055. PMID: 32528386; PMCID: PMC7264369.
6. Neurocognitive outcome
Jernej, R. et al. (2025) ‘Impact of being small for gestational age in neonates born below 600 g birth weight’, Pediatric Research [Preprint]. Available at: https://doi.org/10.1038/s41390-025-04202-x.
Wellmann S, Hagmann CF, von Felten S, Held L, Klebermass-Schrehof K, Truttmann AC, Knöpfli C, Fauchère JC, Bührer C, Bucher HU, Rüegger CM; Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants (EpoRepair) Investigators. Safety and Short-term Outcomes of High-Dose Erythropoietin in Preterm Infants With Intraventricular Hemorrhage: The EpoRepair Randomized Clinical Trial. JAMA Netw Open. 2022 Dec 1;5(12):e2244744. doi: 10.1001/jamanetworkopen.2022.44744. PMID: 36459138; PMCID: PMC9719050.
Bellach L, Eigenschink M, Hassanein A, Savran D, Salzer U, Müllner EW, Repa A, Klebermass-Schrehof K, Wisgrill L, Giordano V, Berger A. Packed red blood cell transfusion in preterm infants. Lancet Haematol. 2022 Aug;9(8):e615-e626. doi: 10.1016/S2352-3026(22)00207-1. PMID: 35901846.
Goeral K, Fuiko R, Binder J, Lindtner C, Jernej R, Rittenschober-Boehm J, Klebermass-Schrehof K, Berger A, Grill A. Considerable mortality and morbidity in neonates born below 500 gram. Acta Paediatr. 2021 Aug;110(8):2359-2365. doi: 10.1111/apa.15885. Epub 2021 May 19. PMID: 33955057; PMCID: PMC8360180.
Fuiko R, Oberleitner-Leeb C, Klebermass-Schrehof K, Berger A, Brandstetter S, Giordano V. The Impact of Norms on the Outcome of Children Born Very-Preterm when Using the Bayley-III: Differences between US and German Norms. Neonatology. 2019;116(1):29-36. doi: 10.1159/000497138. Epub 2019 Mar 19. PMID: 30889586.
Giordano V, Fuiko R, Leiss U, Brandstetter S, Hayde M, Bartha-Doering E, Klebermaß-Schrehof K, Weiler LJ. Differences in attentional functioning between preterm and full-term children underline the importance of new neuropsychological detection techniques. Acta Paediatr. 2017 Apr;106(4):601-611. doi: 10.1111/apa.13723. Epub 2017 Feb 1. PMID: 28004417.
Vignolle GA, Bauerstätter P, Schönthaler S, Nöhammer C, Olischar M, Berger A, Kasprian G, Langs G, Vierlinger K, Goeral K. Predicting Outcomes of Preterm Neonates Post Intraventricular Hemorrhage. Int J Mol Sci. 2024 Sep 25;25(19):10304. doi: 10.3390/ijms251910304. PMID: 39408633; PMCID: PMC11477204.
Goeral K, Hauck A, Atkinson A, Wagner MB, Pimpel B, Fuiko R, Klebermass-Schrehof K, Leppert D, Kuhle J, Berger A, Olischar M, Wellmann S. Early life serum neurofilament dynamics predict neurodevelopmental outcome of preterm infants. J Neurol. 2021 Jul;268(7):2570-2577. doi: 10.1007/s00415-021-10429-5. Epub 2021 Feb 10. PMID: 33566157; PMCID: PMC8217001.